CD152 antibodies, human

CD152 antibodies, human

Clone: BNI3 | Dilution: 1:10
The monoclonal antibody BNI3 reacts with human CD152, an integral membrane protein of the immunoglobin superfamily which is also called CTLA-4. CD152 is a negative regulator of T cell activation. It is transiently expressed on activated CD28
+
T cells and is a ligand for CD80 and CD86. CD4
+
FoxP3
+
regulatory T cells are reported to constitutively express CD152. CD152 may also be detected on B cells when cultured with activated T cells.

Alternative names

CTLA4, ALPS5, CD, CELIAC3, CTLA-4, GRD4, GSE, IDDM12

Technical specifications

  • Antigen: CD152
  • Clone: BNI3
  • Isotype: mouse IgG2aκ
  • Isotype control: Mouse IgG2a – isotype control antibodies
  • Alternative names of antigen: CTLA4, ALPS5, CD, CELIAC3, CTLA-4, GRD4, GSE, IDDM12
  • Entrez Gene ID: 1493
  • Molecular mass of antigen [kDa]: 21
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    chimpanzee (
    Pan troglodytes
    )
    ,
    olive baboon (
    Papio anubis
    )
  • Distribution of antigen: B cells, lymphocytes, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC
  • Selected references

    1. Sansom, D. M. and Walker, L. S. (2006) The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology. Immunol. Rev. 212: 131-148
    2. Kuiper, H. M. et al. (1995) Activated T cells can induce high levels of CTLA-4 expression on B cells. J. Immunol. 155(4): 1776-1783
    3. Castan, J. et al. (1997) Accumulation of CTLA-4 expressing T lymphocytes in the germinal centres of human lymphoid tissues. Immunology 90(2): 265-271
    4. Schlotmann, T. et al. (2000) CD alphabeta T lymphocytes express high levels of the T lymphocyte antigen CTLA-4 (CD152) in acute malaria. J. Infect. Dis. 182(1): 367-370
Product options: 1
130-097-682

CD152-APC, human

for 100
tests
(1)
DKK 2.200,00