Anti-THEMIS antibodies, mouse

Anti-THEMIS antibodies, mouse

Clone: REA659 | Dilution: 1:50
Clone REA659 recognizes the mouse THEMIS antigen, a cytosolic protein also known as Gasp or Grb2-associating protein. THEMIS is only expressed in T cells, highly expressed in thymocytes, especially in immature CD4
+
/CD8
+
thymocytes, and lower expressed in mature T cells. THEMIS plays an important role in positive selection and in the development of single-positive thymocytes.
Additional information: Clone REA659 displays negligible binding to Fc receptors.

Alternative names

Grb2-associating protein, GASP, E430004N04Rik, SPOT, TSEPA, thylex

Technical specifications

  • Antigen: THEMIS
  • Clone: REA659
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Grb2-associating protein, GASP, E430004N04Rik, SPOT, TSEPA, thylex
  • Entrez Gene ID: 210757
  • Molecular mass of antigen [kDa]: 73
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected references

    1. Lesourne, R. et al. (2009) Themis, a T cell-specific protein important for late thymocyte development. Nat. Immunol. 10(8): 840-847
    2. Fu, G. et al. (2009) Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nat. Immunol. 10(8): 848-856
    3. Patrick, M. S. et al. (2009) Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes. Proc. Natl. Acad. Sci. U.S.A. 106(38): 16345-16350
Product options: 2
130-114-213

Anti-THEMIS-PE, mouse

30 µg in 200 µL (1)
DKK 650,00 
130-114-214

Anti-THEMIS-PE, mouse

150 µg in 1 mL (1)
DKK 1.900,00