Anti-PKCα antibodies, human

Anti-PKCα antibodies, human

Clone: REA156 | Dilution: 1:11
Clone REA156 recognizes the PKCα antigen regardless of its phosphorylation status. It has been reported to cross-react with PKCβ. PKCα is a serine- and threonine-specific protein kinase that can be activated by calcium and the second messenger diacylglycerol. It plays a role in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. PKCα is highly expressed in a number of cancer cells where it can acts as a tumor promoter and it is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca
2+
handling in myocytes.
Additional information: Clone REA156 displays negligible binding to Fc receptors.

Alternative names

PRKCA, AAG6, PKC-alpha, PRKACA, PKC-A

Technical specifications

  • Antigen: PKCα
  • Clone: REA156
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: PRKCA, AAG6, PKC-alpha, PRKACA, PKC-A
  • Entrez Gene ID: 5578
  • Molecular mass of antigen [kDa]: 77
  • Cross-reactivity: mouse, rat, dog, chicken, frog
  • Distribution of antigen: other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PerCP-Vio700
  • Selected references

    1. Finkenzeller, G. et al. (1990) Sequence of human protein kinase C alpha. Nucleic Acids Res. 18(8): 2183
    2. Koivunen, J. et al. (2006) Protein kinase C (PKC) family in cancer progression. Cancer Lett. 235(1): 1-10
    3. Xu, H. et al. (2008) Protein kinase C alpha promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor. Cardiovasc. Res. 78(2): 349-355
Product options: 6
for 30
tests
(1)
DKK 900,00 
for 100
tests
(1)
DKK 2.200,00 
for 30
tests
(1)
DKK 900,00 
for 100
tests
(1)
DKK 2.200,00 
for 30
tests
(1)
DKK 1.000,00 
for 100
tests
(1)
DKK 2.400,00 

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