Anti-O4 antibodies, human, mouse, rat

Anti-O4 antibodies, human, mouse, rat

Clone: REA576 | Dilution: 1:50
Clone REA576 recognizes the human, mouse, and rat O4 antigen, a marker for oligodendrocytes, which are a type of glial cells. Their function is to provide a supporting role for neurons. During oligodendrocyte development, late A2B5
+
oligodendrocyte progenitors start to express O4. As the cells differentiate, A2B5 expression ceases, whereas O4 expression persists. More mature cells start to synthesize galactocerebroside, MBP, PLP, MOG, and O1. O4 expression is found on Schwann cells in the peripheral nervous system.
Additional information: Clone REA576 displays negligible binding to Fc receptors.

Alternative names

Oligodendrocyte marker O4

Technical specifications

  • Antigen: O4
  • Clone: REA576
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Oligodendrocyte marker O4
  • Distribution of antigen: Schwann cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, VioBright 515
  • Selected references

    1. Sommer, I. and Schachner, M. (1981) Monoclonal antibodies (O1 to O4) to oligodendrocyte cell surfaces: an immunocytological study in the central nervous system. Dev. Biol. 83: 311-327
    2. Bansal, R. et al. (1989) Multiple and novel specificities of monoclonal antibodies O1, O4, and R-mAb used in the analysis of oligodendrocyte development. J. Neurosci. Res. 24(4): 548-557
    3. Zhang, S.C. (2001) Defining glial cells during CNS development. Nat. Rev. Neurosci. 2: 840-843
Product options: 6
130-117-823

Anti-O4-PE, human, mouse, rat

for 30
tests
(1)
DKK 950,00 
130-117-711

Anti-O4-PE, human, mouse, rat

for 100
tests
(1)
DKK 2.250,00 
130-119-982

Anti-O4-APC, human, mouse, rat

for 30
tests
(1)
DKK 950,00 
130-119-897

Anti-O4-APC, human, mouse, rat

for 100
tests
(1)
DKK 2.250,00 
130-120-102

Anti-O4-VioBright 515, human, mouse, rat

for 30
tests
(1)
DKK 1.250,00 
130-120-016

Anti-O4-VioBright 515, human, mouse, rat

for 100
tests
(1)
DKK 3.005,00