Anti-GARP (LRRC32) antibodies, human

Anti-GARP (LRRC32) antibodies, human

Clone: REA166 | Dilution: 1:11
Clone REA166 recognizes the human glycoprotein A repetitions predominant (GARP) antigen, a 80 kDa type I membrane glycoprotein which belongs to the family of leucine rich repeat proteins. Expression of GARP protein is found on megakaryocytes, platelets, and activated regulatory T cells (Treg cells). GARP has been found to be associated with latency associated peptide (LAP), the prodomain responsible for conferring latency to non-active TGF-β. Thus, GARP as a latent TGF-β–binding protein (LTBP) regulates the surface expression of TGF-β and serves as a carrier of LAP, at the cell surface, to immune response active sites, where TGF-β is eventually activated and released to exert further physiological functions such as differentiation of regulatory T cells.
Additional information: Clone REA166 displays negligible binding to Fc receptors.

Alternative names

LRRC32, D11S833E, Glycoprotein A repetitions predominant (GARP)

Technical specifications

  • Antigen: GARP (LRRC32)
  • Clone: REA166
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: LRRC32, D11S833E, Glycoprotein A repetitions predominant (GARP)
  • Entrez Gene ID: 2615
  • Molecular mass of antigen [kDa]: 70
  • Distribution of antigen: platelets, other, T cells, monocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
  • Selected references

    1. Zhou, A. X. et al. (2013)
      GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4
      +
      T cells
      in vivo
      .
      J. Immunol. 190(10): 5057-5064
    2. Tran, D. Q. et al. (2009)
      GARP (LRRC32) is essential for the surface expression of latent TGF-β on platelets and activated FOXP3
      +
      regulatory T cells.
      Proc. Natl. Acad. Sci. U.S.A. 106: 13445-13450
    3. Ollendorff, V. et al. (1994) The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins. Cell Growth Differ. 5: 213-219
Product options: 6
130-103-889

Anti-GARP (LRRC32)-PE, human

for 30
tests
(1)
DKK 900,00 
130-103-819

Anti-GARP (LRRC32)-PE, human

for 100
tests
(1)
DKK 2.200,00 
130-103-890

Anti-GARP (LRRC32)-APC, human

for 30
tests
(1)
DKK 900,00 
130-103-820

Anti-GARP (LRRC32)-APC, human

for 100
tests
(1)
DKK 2.200,00 
130-104-362

Anti-GARP (LRRC32)-Biotin, human

for 30
tests
(1)
DKK 750,00 
130-104-313

Anti-GARP (LRRC32)-Biotin, human

for 100
tests
(1)
DKK 1.850,00