CD20 MicroBeads, human

CD20 MicroBeads, human

CD20 MicroBeads were developed for positive selection or depletion of human CD20
+
B cells from different cell sources such as human PBMCs, bone marrow, cell cultures or lymphoid tissues.

Background information

CD20 is a non-glycosylated transmembrane protein of 33–37 kDa that becomes heavily phosphorylated upon activation
1,2
. It is expressed exclusively on B cells, including pre-B cells, naive, mature, and activated B cells, B cell blasts, and the majority of malignant B cells, but not on early B cell progenitors or plasma cells
2,3
.

Downstream applications

Purified CD20
+
B cells may be used in cell biological studies, such as analysis of signal transduction, chemotaxis, allergen response, apoptosis, or in molecular studies, e.g., subset-specific microarrays.

Columns

For positive selection: MS, LS, XS, or autoMACS
®
Columns. For depletion: LD, D, or autoMACS Columns.
  • Selected references

    1. Chang et al. (1996) Appl. Immunohistochem. 4: 1-15
    2. Polyak et al. (2002) CD20 Workshop Panel report. In: Leucocyte typing VII, Oxford University Press.
    3. Countouriotis, A. et al. (2002) Cell surface antigen and molecular targeting in the treatment of hematologic malignancies. Stem Cells 20: 215-229
    4. Cragg, M. S. et al. (2002) Opposing properties of CD20 mAb. In: Leucocyte typing VII, Oxford University Press.
Product options: 1
for 1×
10
9
total cells
DKK 3.970,00 

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