Mouse M-CSF

Mouse M-CSF

M-CSF stands for macrophage-colony stimulating factor. Mouse M-CSF is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Mouse M-CSF can be used for a variety of applications, including:
  • Generation of bone marrow-derived macrophages.
  • Differentiation of osteoclasts.
  • Proliferation and apoptosis assays.

Background information

Macrophage-colony stimulating factor (M-CSF), a four α-helical bundle cytokine, is a potent hematopoietic regulator. It is primarily produced by monocytes, granulocytes, endothelial cells, and fibroblasts. The main function of M-CSF is the regulation of proliferation, differentiation, and survival of monocytes, macrophages and their hematopoietic progenitors. Furthermore, M-CSF has been shown to play an important role in immunological defense, bone metabolism, fertility, and pregnancy.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Proliferation of M-NFS-60 cells
  • premium grade: ≥ 2×
    10
    5
    U/mg
  • research grade: ≥ 1×
    10
    5
    U/mg
  • Selected references

    1. Guery L. et al. (2014) Fine-tuning nucleophosmin in macrophage differentiation and activation. Blood 118: 4694-4704
    2. Tanne, A. et al. (2009)
      A murine DC-SIGN homologue contributes to early host defense against
      Mycobacterium tuberculosis
      .
      J. Exp. Med. 206(10): 2205-2220
    3. Tanne, A. et al. (2009)
      A murine DC-SIGN homologue contributes to early host defense against
      Mycobacterium tuberculosis
      .
      J. Exp. Med. 206: 2205-2220
    4. Herold, J. et al. (2014) Tetanus toxoid-pulsed monocyte vaccination for augmentation of collateral vessel growth. J Am Heart Assoc. 3(2): e000611
Product options: 6
E. coli
10 µg
DKK 1.195,00 
E. coli
25 µg
DKK 2.235,00 
E. coli
10 µg
DKK 1.465,00 
E. coli
25 µg
DKK 2.810,00 
E. coli
100 µg
DKK 4.850,00 
E. coli
1000 µg
DKK 21.175,00