Name: CD140b pY857 Antibody, anti-mouse, REAfinity™
Availability: InStock

Intracellular flow cytometry

Conjugate:	APC
Recommended dilution:	1:10
Remark:	The antibody is suited for staining of formaldehyde-fixed cells.
Tested:	QC tested
Products used:	130-109-793, 130-109-746

Specifications for CD140b pY857 Antibody, anti-mouse, REAfinity™

Overview

Clone REA628 recognizes the mouse CD140b antigen phosphorylated at tyrosine 857 (pY857). CD140b is a single-pass type I membrane protein also known as platelet-derived growth factor receptor beta (PDGFR-beta). PDGFR is composed of PDGFRα (CD140a) and/or PDGFRβ (CD140b) molecules. CD140b is broadly expressed in embryonic tissue and in cells of mesodermal origin, in adult tissue as fibroblasts, smooth muscle cells, glial cells, and chondrocytes. It is a tyrosine-protein kinase and receptor dimerization and transphosphorylation at tyrosine residues activates the intracellular kinase activity. CD140b plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis, and migration.

Additional information: Clone REA628 displays negligible binding to Fc receptors.

Alternative names

PDGF-R-beta, PDGFR-beta, PDGFR-1, AI528809, Pdgfr

Detailed product information

Technical specifications

Clone	REA628
Clonality	monoclonal
Isotype	recombinant human IgG1
Isotype control	REA Control Antibody, human IgG1
Host	cell line
Type of antibody	Primary antibodies, Recombinant antibodies
Species	mouse, human
Cross-reactivity	human
Antigen	CD140b pY857
Alternative names of antigen	PDGF-R-beta, PDGFR-beta, PDGFR-1, AI528809, Pdgfr
Molecular mass of antigen [kDa]	120
Distribution of antigen	chondrocytes, fibroblasts
Entrez Gene ID	18596
RRID	AB_2655105, AB_2655106, AB_2655107, AB_2655104

References for CD140b pY857 Antibody, anti-mouse, REAfinity™

Publications

Gao, B. B. et al. (2006) Angiotensin II stimulates phosphorylation of an ectodomain-truncated platelet-derived growth factor receptor-beta and its binding to class IA PI3K in vascular smooth muscle cells. Biochem. J. 397(2): 337-344
Fiaschi, T. et al. (2003) Down-regulation of platelet-derived growth factor receptor signaling during myogenesis. Cell. Mol. Life Sci. 60(12): 2721-2735
Getachew, R. et al. (2010) PDGF beta-receptor kinase activity and ERK1/2 mediate glycosaminoglycan elongation on biglycan and increases binding to LDL. Endocrinology 151(9): 4356-4367

Applications

Specifications

Specifications for CD140b pY857 Antibody, anti-mouse, REAfinity™

Overview

Additional information: Clone REA628 displays negligible binding to Fc receptors.

Alternative names

PDGF-R-beta, PDGFR-beta, PDGFR-1, AI528809, Pdgfr

Detailed product information

Technical specifications

Clone	REA628
Clonality	monoclonal
Isotype	recombinant human IgG1
Isotype control	REA Control Antibody, human IgG1
Host	cell line
Type of antibody	Primary antibodies, Recombinant antibodies
Species	mouse, human
Cross-reactivity	human
Antigen	CD140b pY857
Alternative names of antigen	PDGF-R-beta, PDGFR-beta, PDGFR-1, AI528809, Pdgfr
Molecular mass of antigen [kDa]	120
Distribution of antigen	chondrocytes, fibroblasts
Entrez Gene ID	18596
RRID	AB_2655105, AB_2655106, AB_2655107, AB_2655104

References

References for CD140b pY857 Antibody, anti-mouse, REAfinity™

Publications

Gao, B. B. et al. (2006) Angiotensin II stimulates phosphorylation of an ectodomain-truncated platelet-derived growth factor receptor-beta and its binding to class IA PI3K in vascular smooth muscle cells. Biochem. J. 397(2): 337-344
Fiaschi, T. et al. (2003) Down-regulation of platelet-derived growth factor receptor signaling during myogenesis. Cell. Mol. Life Sci. 60(12): 2721-2735
Getachew, R. et al. (2010) PDGF beta-receptor kinase activity and ERK1/2 mediate glycosaminoglycan elongation on biglycan and increases binding to LDL. Endocrinology 151(9): 4356-4367

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CD140b pY857 Antibody, anti-mouse, REAfinity™

CD140b pY857 Antibody, anti-mouse, REAfinity™

Intracellular flow cytometry

Specifications for CD140b pY857 Antibody, anti-mouse, REAfinity™

Overview

Alternative names

Detailed product information

Technical specifications

References for CD140b pY857 Antibody, anti-mouse, REAfinity™

Publications

Specifications for CD140b pY857 Antibody, anti-mouse, REAfinity™

Overview

Alternative names

Detailed product information

Technical specifications

References for CD140b pY857 Antibody, anti-mouse, REAfinity™

Publications

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CD140b pY857 Antibody, anti-mouse, REAfinity™