CD37 antibodies, human

CD37 antibodies, human

Clone: REA366 | Dilution: 1:11
Clone REA366 recognizes the human CD37 antigen, a multi-pass membrane protein which is also known as tetraspanin-26 (Tspan-26). CD37 is a member of the transmembrane 4 superfamily of tetraspanin proteins, which consist of 4 potential membrane-spanning regions, 2 extracellular loops, and 2 short intracytoplasmic tails. Although most tetraspanins are ubiquitous proteins, CD37 expression is nearly exclusively limited to mature B cells and B cell–derived lymphoid malignancies. B cell early progenitors, T cells, natural killer cells, and myeloid cells exhibit only minimal amounts of membrane-associated CD37. In innate immunity, CD37 interacts with pattern recognition receptor dectin-1, stabilizing dectin-1 at the macrophage cell surface, and negatively regulating proinflammatory cytokine secretion following ligand recognition. Adaptive humoral immune responses are also perturbed by CD37 ablation. In cellular immunity, CD37 negatively regulates T cell proliferation. In APCs, CD37 associates with MHC class II at the cell surface and has been shown to negatively regulate antigen presentation. CD37 has recently attracted interest as a target for monoclonal antibodies with therapeutic potential in B cell malignancies.
Additional information: Clone REA366 displays negligible binding to Fc receptors.

Alternative names

GP52-40, TSPAN26

Technical specifications

  • Antigen: CD37
  • Clone: REA366
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: GP52-40, TSPAN26
  • Entrez Gene ID: 951
  • Molecular mass of antigen [kDa]: 32
  • Distribution of antigen: B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Schwartz-Albiez, R. et al. (1988) The B cell-associated CD37 antigen (gp40-52). Structure and subcellular expression of an extensively glycosylated glycoprotein. J. Immunol. 140(3): 905-914
    2. Classon, B. J. et al. (1989) The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen. J. Exp. Med. 169(4): 1497-1502
    3. Gartlan, K. H. et al. (2013) Tetraspanin CD37 contributes to the initiation of cellular immunity by promoting dendritic cell migration. Eur. J. Immunol. 43(5): 1208-1219
Product options: 16
130-105-285

CD37-FITC, human

for 30
tests
(1)
EUR 75,00 
130-105-243

CD37-FITC, human

for 100
tests
(1)
EUR 185,00 
130-105-286

CD37-PE, human

for 30
tests
(1)
EUR 90,00 
130-105-244

CD37-PE, human

for 100
tests
(1)
EUR 220,00 
130-105-287

CD37-APC, human

for 30
tests
(1)
EUR 90,00 
130-105-245

CD37-APC, human

for 100
tests
(1)
EUR 220,00 
for 30
tests
(1)
EUR 95,00 
for 100
tests
(1)
EUR 230,00 
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 
for 30
tests
(1)
EUR 75,00 
for 100
tests
(1)
EUR 185,00 

Related products

2 products available