CD357 (GITR) antibodies – functional grade, human

CD357 (GITR) antibodies – functional grade, human

Clone: DT5D3
CD357, also known as glucocorticoid-induced tumor necrosis factor receptor–related protein (GITR) or TNFRSF18, is an inducible type I transmembrane protein and member of the tumor necrosis factor receptor (TNFR) superfamily.
CD357 is expressed at low levels on thymocyte subsets, resting T cells, B cells, macrophages, and at high levels on CD4
+
CD25
+
regulatory T cells (Tregs). Upon activation, expression on CD4
+
and CD8
+
T cells is upregulated. Triggering of CD357 has been described to modulate Treg function and costimulate effector T cells. Stimulation of T cells through CD357 can abrogate the inhibitory function of Tregs. It is hypothesized that CD357 has a role in the maintenance of immunological self tolerance, and mouse models of autoimmune disease suggest that CD357 activation may break self-tolerance and induce autoimmunity.

Applications

The CD357 (GITR) pure – functional grade antibody is suited for functional assays, for example,
in vitro
inhibition of GITRL binding.

Alternative names

TNFRSF18, AITR, GITR-D

Technical specifications

  • Antigen: CD357 (GITR)
  • Clone: DT5D3
  • Isotype: mouse IgG1
  • Alternative names of antigen: TNFRSF18, AITR, GITR-D
  • Entrez Gene ID: 8784
  • Molecular mass of antigen [kDa]: 24
  • Endotoxin level: Endotoxin levels have been tested and do not exceed 0.01 ng/µg of protein.
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
  • Selected references

    1. Shimizu, J. et al. (2002)
      Stimulation of CD25
      +
      CD4
      +
      regulatory T cells through GITR breaks immunological self-tolerance.
      Nat. Immunol. 3(2): 135-142
    2. Nocentini, G. et al. (1997) A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc. Natl. Acad. Sci. U.S.A. 94: 6216-6221
    3. Nocentini, G. et al. (2007) GITR/GITRL: more than an effector T cell co-stimulatory system. Eur. J. Immunol. 37: 1165-1169
    4. Gurney, A. L. et al. (1999) Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. Curr. Biol. 9: 215-218
Product options: 1
500 µg in 0.5 mL
-

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