CD344 (Frizzled-4) antibodies, human

CD344 (Frizzled-4) antibodies, human

Clone: CH3A4A7 | Dilution: 1:11
Clone CH3A4A7 recognizes an extracellular epitope of the human CD344 antigen, a multi-pass membrane protein which is also known as Frizzled family receptor 4 (FZD4) or Frizzled-4. CD344 is expressed by neuronal stem cells and also found on fetal neuronal progenitor cells and neuronal intestinal cells. It is a member of the Frizzled family of proteins which encode seven-transmembrane domain proteins that are receptors for the wingless-type MMTV integration site family of signaling proteins. CD344 is involved in the activation of Wnt/β-catenin pathway (canonic Wnt signaling). It is the only representative of frizzled family members that binds strongly an additional ligand norrin that is functionally similar but structurally different from wingless-type proteins. CD344 signaling induced by norrin regulates vascular development of vertebrate retina and controls important blood vessels in the ear.

Alternative names

FZD4, EVR1, FEVR, FZD4S, Fz-4, Fz4, FzE4, GPCR, hFz4

Technical specifications

  • Antigen: CD344 (Frizzled-4)
  • Clone: CH3A4A7
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: FZD4, EVR1, FEVR, FZD4S, Fz-4, Fz4, FzE4, GPCR, hFz4
  • Entrez Gene ID: 8322
  • Molecular mass of antigen [kDa]: 56
  • Distribution of antigen: neural stem cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, PerCP-Vio700
  • Selected references

    1. Kirikoshi, H. et al. (1999) Molecular cloning and characterization of human Frizzled-4 on chromosome 11q14-q21. Biochem. Biophys. Res. Commun. 264(3): 955-961
    2. Ye, X. et al. (2009) Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. Cell 139(2): 285-298
    3. Descamps, B. et al. (2012) Frizzled 4 regulates arterial network organization through noncanonical Wnt/planar cell polarity signaling. Circ. Res. 110(1): 47-58
Product options: 8
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 

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