CD307e (FcRL5) antibodies, human

CD307e (FcRL5) antibodies, human

Clone: REA391 | Dilution: 1:11
Clone REA391 recognizes the human CD307e antigen, a 106 kDa single-pass type I membrane protein also known as Fc receptor-like protein 5 (FcRL5) or immune receptor translocation-associated protein 2 (IRTA2). CD307e possesses a cytoplasmic tail with inhibitory ITIM phosphorylation signaling motifs and was found to inhibit B cell antigen receptor signaling by recruiting SHP1 to two ITIM motifs upon B cell antigen receptor co-stimulation, resulting in diminished calcium influx and protein tyrosine phosphorylation. Co-stimulation of CD307e and the B cell antigen receptor promotes proliferation and differentiation of naive B cells. CD307e is expressed on both mature B cells and plasma cells, and is induced by EBV proteins. It is overexpressed on malignant B cells of hairy cell leukemia, chronic lymphocytic leukemia, mantle cell lymphoma, and multiple myeloma patients. In addition, serum levels of soluble CD307e are elevated in patients with several types of B cell tumors.
Additional information: Clone REA391 displays negligible binding to Fc receptors.

Alternative names

FCRL5, BXMAS1, CD307, FCRH5, IRTA2, PRO820

Technical specifications

  • Antigen: CD307e (FcRL5)
  • Clone: REA391
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: FCRL5, BXMAS1, CD307, FCRH5, IRTA2, PRO820
  • Entrez Gene ID: 83416
  • Molecular mass of antigen [kDa]: 105
  • Distribution of antigen: B cells, plasma cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Biotin
  • Selected references

    1. Miller, I. et al. (2002) IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells. Blood 99(8): 2662-2669
    2. Zhu, Z. et al. (2013) FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling. Proc. Natl. Acad. Sci. U.S.A. 110(14): E1282-E1290
    3. Nakayama, Y. et al. (2001) BXMAS1 identifies a cluster of homologous genes differentially expressed in B cells. Biochem. Biophys. Res. Commun. 285(3): 830-837
Product options: 8
for 30
tests
(1)
EUR 75,00 
for 100
tests
(1)
EUR 185,00 
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 
for 30
tests
(1)
EUR 75,00 
for 100
tests
(1)
EUR 185,00 

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