CD304 (BDCA-4) antibodies, mouse

CD304 (BDCA-4) antibodies, mouse

Clone: REA380 | Dilution: 1:10
Clone REA380 recognizes the mouse CD304 antigen, a single-pass type I membrane protein also known as neuropilin-1 or blood dendritic cell antigen-4 (BDCA-4). There are differences in the CD304 expression between mice and humans. In mice, CD304 is selectively expressed on natural T regulatory cells and greatly enhances immunosuppressive function. It is also expressed on a subset of invariant natural killer T cells, endothelial cells, and neurons. In humans, CD304 is expressed on plasmacytoid dendritic cells where it aids in priming immune responses and on a subset of T regulatory cells isolated from secondary lymph nodes. CD304 acts as a coreceptor for a number of extracellular ligands including class III/IV semaphorins, certain isoforms of vascular endothelial growth factor and transforming growth factor beta. It is involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits, and in organogenesis outside the nervous system.
Additional information: Clone REA380 displays negligible binding to Fc receptors.

Alternative names

NRP1, NP-1, NPN-1, Nrp

Technical specifications

  • Antigen: CD304
  • Clone: REA380
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: NRP1, NP-1, NPN-1, Nrp
  • Entrez Gene ID: 18186
  • Molecular mass of antigen [kDa]: 101
  • Distribution of antigen: dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, PE
  • Selected references

    1. Delgoffe, G. M. et al. (2013) Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. Nature 501(7466): 252-256
    2. Yadav, M. et al. (2012)
      Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets
      in vivo
      .
      J. Exp. Med. 209(10): 1713-1722
    3. Kawakami, A. et al. (1996) Developmentally regulated expression of a cell surface protein, neuropilin, in the mouse nervous System. J. Neurobiol. 29(1): 1-17
    4. Smith, N. et al. (2017) Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement. Nat Commun 8: 14253
Product options: 2
9 µg in 300 µL (1)
EUR 48,00 
30 µg in 1 mL (1)
EUR 65,00