CD294 (CRTH2) antibodies, human

CD294 (CRTH2) antibodies, human

Clone: REA598 | Dilution: 1:50
Clone REA598 recognizes the CD294 antigen, also known as chemoattractant receptor-homologous molecule expressed on Tʜ2 cells (CRTH2). CD294 is a seven-transmembrane G protein–coupled receptor for prostaglandin D2 involved in migration of leukocytes and is expressed on T helper type 2 (Tʜ2) cells, a subpopulation of CD4
+
T cells, but not on Tʜ1 cells. The CD294 antigen is highly expressed on peripheral blood basophils and eosinophils. It is also present on a small population of CD8
+
T cells and on a subpopulation of dendritic cells (DCs).
Additional information: Clone REA598 displays negligible binding to Fc receptors.

Alternative names

CRTH2

Technical specifications

  • Antigen: CD294 (CRTH2)
  • Clone: REA598
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CRTH2
  • Entrez Gene ID: 11251
  • Molecular mass of antigen [kDa]: 43
  • Distribution of antigen: T helper cells, basophils, eosinophils, T cells, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Nagata, K. et al. (1999)
      Selective expression of a novel surface molecule by human Tʜ2 cells
      in vivo
      .
      J. Immunol. 162: 1278-1286
    2. Messi, M. et al. (2003) Memory and flexibility of cytokine gene expression as separable properties of human Tʜ1 and Tʜ2 lymphocytes. Nat. Immunol. 4: 78-86
    3. Nagata, K. et al. (1999) CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s). FEBS Lett. 459: 195-199
Product options: 10
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 
for 30
tests
(1)
EUR 75,00 
for 100
tests
(1)
EUR 185,00 

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