CD28 antibodies, human

CD28 antibodies, human

Clone: REA612 | Dilution: 1:50
Clone REA612 recognizes the human CD28 antigen, a type I transmembrane protein, which is highly expressed on CD3
+
thymocytes, most peripheral thymocytes, and plasma cells but not in less mature B cells. Binding of CD28 to its ligands CD80 or CD86 costimulates T cell effector function and T cell–dependent antibody production
in vitro
and
in vivo
. In the presence of antibodies directed against CD2 and CD3, CD28 antibodies stimulate T cell proliferation and cytokine production.
Additional information: Clone REA612 displays negligible binding to Fc receptors.

Alternative names

T44, Tp44

Technical specifications

  • Antigen: CD28
  • Clone: REA612
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: T44, Tp44
  • Entrez Gene ID: 940
  • Molecular mass of antigen [kDa]: 23
  • Distribution of antigen: B cells, lymphocytes, plasma cells, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, APC, APC-Vio770, PE-Vio615, PE
  • Selected references

    1. Kozbor D. J. et al. (1987) Tp44 molecules involved in antigen-independent T cell activation are expressed on human plasma cells. J. Immunol. 138(12): 4128-4132
    2. Bahlis, N. J. et al. (2007) CD28-mediated regulation of multiple myeloma cell proliferation and survival. Blood 109(11): 5002-5010
    3. Krummel, M. F. and Allison, J. P. (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182(2): 459-465
    4. Freeman, G. J. et al. (1993) Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. Science 262(5135): 909-911
    5. Linsley, P. S. et al. (1993) The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11: 191-212
    6. June, C. H. et al. (1990) Role of the CD28 receptor in T-cell activation. Immunol. Today 11(6): 211-216
Product options: 10
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 
130-118-482

CD28-APC, human

for 30
tests
(1)
EUR 90,00 
130-118-343

CD28-APC, human

for 100
tests
(1)
EUR 220,00 
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 
130-124-002

CD28-PE, human

for 30
tests
(1)
EUR 90,00 
130-123-782

CD28-PE, human

for 100
tests
(1)
EUR 220,00 

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