CD278 (ICOS) antibodies, human, mouse, rat

CD278 (ICOS) antibodies, human, mouse, rat

Clone: REA192
Clone REA192 recognizes CD278 (ICOS), which belongs to the CD28 family of proteins. CD28 family members are costimulatory receptor molecules, contain single immunoglobulin V-like domain, and belong to the immunoglobulin superfamily. CD287 recognizes inducible T cell costimulator ligand (ICOSL) as ligand and its expression is induced on activated T cells. Enhanced expression of CD278 is also observed on T cells, followed by costimulation of T cells via CD28. Further expression of CD278 is found on B cells, monocytes, and dendritic cells. Crosslinking of ICOS on T cell surface in the presence of primary stimulation signal leads to T cell proliferation and differentiation. In addition, CD278 plays role in Tʜ cell differentiation, effector T cell function, and isotype class switching.
Additional information: Clone REA192 displays negligible binding to Fc receptors.

Alternative names

ICOS, AILIM, CVID1

Technical specifications

  • Antigen: CD278 (ICOS)
  • Clone: REA192
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ICOS, AILIM, CVID1
  • Distribution of antigen: T cells
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates:
Product options: 1
100 µg in 100 µL
EUR 144,00