CD206 antibodies, human

CD206 antibodies, human

Clone: DCN228 | Dilution: 1:50
The mannose receptor (MR), also known as macrophage MR or CD206, is a 162–175 kDa type I membrane protein. It contains an N-terminal cystein-rich domain and eight C-type lectin-like domains (CTLDs), beside a transmembrane and a cytoplasmic domain. CD206 is expressed by macrophages, dendritic cells, and subsets of endothelial cells, but not on monocytes. The MR recognizes multiple mainly microbial carbohydrates with mannose, fucose, or N-acetyl glucosamine residues. The MR mediates endocytosis and phagocytosis, linked to antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity.

Alternative names

MRC1, CLEC13D, CLEC13DL, MMR, MRC1L1

Technical specifications

  • Antigen: CD206
  • Clone: DCN228
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: MRC1, CLEC13D, CLEC13DL, MMR, MRC1L1
  • Entrez Gene ID: 4360
  • Molecular mass of antigen [kDa]: 164
  • Distribution of antigen: dendritic cells, endothelial cells, macrophages, placenta, plasma cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC
  • Selected references

    1. Tacken, P. J. et al. (2005) Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody. Blood 106: 1278-1285
    2. Ezekowitz, R. A. B. et al. (1990) Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells. J. Exp. Med. 172: 1785-1794
    3. Kang, P. B. et al. (2005) The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis. J. Exp. Med. 202: 987-999
    4. Sallusto, F. et al. (1995) Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartement: downregulation by cytokines and bacterial products.​ J. Exp. Med. 182: 389-400
    5. Wileman, T. E. et al. (1986) Identification of the macrophage mannose receptor as a 175-kDa membrane protein. Proc. Natl. Acad. Sci. U.S.A. 83: 2501-2505
    6. Feinberg, H. et al. (2000) Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor. J. Biol. Chem. 275: 21539-21548
    7. Lennartz, M. R. et al. (1989) Biosynthesis and processing of the mannose receptor in human macrophages. J. Biol. Chem. 264: 2385-2390
    8. Yee Seng Ng (2012) Chemical transfection of dye-conjugated microRNA precursors for microRNA functional analysis of M2 macrophages. J. Cell. Biochem. 113(5): 1714-1723
Product options: 2
for 30
tests
(1)
EUR 75,00 
for 100
tests
(1)
EUR 185,00 

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