CD186 (CXCR6) antibodies, mouse

CD186 (CXCR6) antibodies, mouse

Clone: REA1193 | Dilution: 1:50
Clone REA1193 recognizes the mouse CD186 chemokine receptor, which is also known as Cxcr6 (receptor for the C-X-C chemokine CXCL16). CD186 is expressed by naive CD8 T cells, natural killer T cells, and a subset of memory CD4 T cells.
The chemokine CXCL16 is produced by dendritic cells (DCs) in lymphoid organ T cell zones and by cells in the splenic red pulp. It is reported, that CXCL16 plays a role in promoting interactions between DCs and CD8 T cells and in guiding T cell movements in the splenic red pulp.Furthermore, CXCL16 and CXCR6 play an essential role in the maintenance of cardiac allograft tolerance mediated by NKT cells.
Additional information: Clone REA1193 displays negligible binding to Fc receptors.

Alternative names

CXC-R6, CXCR-6, CXCR6, BONZO, STRL33

Technical specifications

  • Antigen: CD186 (CXCR6)
  • Clone: REA1193
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: CXC-R6, CXCR-6, CXCR6, BONZO, STRL33
  • Entrez Gene ID: 80901
  • Molecular mass of antigen [kDa]: 41
  • Distribution of antigen: T cells, NKT cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, PE-Vio770, Biotin, PE
  • Selected references

    1. Matloubian, M. et al. (2000) A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nat. Immunol. 1(4): 298-304
    2. Jiang, X. et al. (2005) Cutting edge: critical role of CXCL16/CXCR6 in NKT cell trafficking in allograft tolerance. J. Immunol. 175(4): 2051-2055
Product options: 4
30 µg in 200 µL (1)
EUR 65,00 
30 µg in 200 µL (1)
EUR 65,00 
30 µg in 200 µL (1)
EUR 85,00 
30 µg in 200 µL (1)
EUR 35,00