CD18 antibodies, human

CD18 antibodies, human

Clone: REA1112 | Dilution: 1:50
Clone REA1112 recognizes the human CD18 antigen, a type I transmembrane protein with an approximate molecular weight of 90–95 kDa. It non-covalently associates with α subunits CD11a (αL), CD11b (αM), CD11c (αX), and CD11d (αD) to form functional integrins which are expressed on leukocytes. CD18 associated integrins bind several ligands including cell surface and extracellular matrix proteins and are involved in cell-cell and cell-extracellular matrix interactions, immune regulation, and immune tolerance. Leucocytes of patients lacking CD18 or expressing dysfunctional CD18 are defective in chemotaxis, phagocytosis, and homotypic aggregation.
Additional information: Clone REA1112 displays negligible binding to Fc receptors.

Alternative names

ITGB2, LAD, LCAMB, LFA-1, Mac-1 α, MF17

Technical specifications

  • Antigen: CD18
  • Clone: REA1112
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ITGB2, LAD, LCAMB, LFA-1, Mac-1 α, MF17
  • Entrez Gene ID: 3689
  • Molecular mass of antigen [kDa]: 83
  • Cross-reactivity: porcine
  • Distribution of antigen: leukocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE-Vio615, PE-Vio770
  • Selected references

    1. Barber, D. F. et al. (2004) LFA-1 contributes an early signal for NK cell cytotoxicity. J. Immunol. 173(6): 3653-3659
    2. Tan, S. M. (2012) The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties. Biosci. Rep. 32(3): 241-269
Product options: 4
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00