CD166 antibodies, human

CD166 antibodies, human

Clone: REA442 | Dilution: 1:11
Clone REA442 recognizes the human CD166 antigen, a single-pass type I membrane protein also known as activated leukocyte cell adhesion molecule (ALCAM). CD166, a member of the immunoglobulin superfamily and a ligand for the lymphocyte antigen CD6, mediates homophilic and heterophilic adhesion. It is expressed on activated leukocytes T cells, B cells, monocytes, hematopoietic stem cells (HSCs), metastasizing melanoma, neuronal cells, endothelial cells, hematopoiesis-supporting osteoblastic cell lines, and mesenchymal stem cells (MSCs). CD166 expression is pathologically correlated with aggressive disease in a variety of cancers including melanoma, prostate, breast, ovarian, esophageal, and bladder cancers. It is also a universal functional marker of murine and human HSCs and osteoblasts within the hematopoietic niche and it is involved in modulating HSC-niche interactions and HSC fate.
Additional information: Clone REA442 displays negligible binding to Fc receptors.

Alternative names

ALCAM, MEMD

Technical specifications

  • Antigen: CD166
  • Clone: REA442
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ALCAM, MEMD
  • Entrez Gene ID: 214
  • Molecular mass of antigen [kDa]: 62
  • Distribution of antigen: hematopoietic stem cells, T cells, B cells, monocytes, melanoma, endothelial cells, mesenchymal stem cells, osteoblasts
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE-Vio770, Biotin
  • Selected references

    1. Chitteti, B. R. et al. (2014) CD166 regulates human and murine hematopoietic stem cells and the hematopoietic niche. Blood 124(4): 519-529
    2. Degen, W. G. et al. (1998) MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule). Am. J. Pathol. 152(3): 805-813
    3. Ni, C. et al. (2013) Prognostic value of CD166 expression in cancers of the digestive system: a systematic review and meta-analysis. PLoS One 8(8): e70958
Product options: 6
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 
for 30
tests
(1)
EUR 75,00 
for 100
tests
(1)
EUR 185,00 

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