CD158a (KIR2DL1) antibodies, human

CD158a (KIR2DL1) antibodies, human

Clone: REA284 | Dilution: 1:11
Clone REA284 recognizes human CD158a (KIR2DL1), but not KIR2DL2, 2DL3, 2DL4, 2DL5, 2DS1, 2DS2, 2DS4, 3DL1, 3DL2, or 3DS1. CD158a is 58 kDa protein, also known as KIR2DL1. CD158a is a member of the family of killer cell immunoglobulin-like receptors (KIRs) comprising transmembrane glycoproteins expressed on NK cells and a subset of T cells. Many groups of KIRs exist including KIR3DL1-3, KIR3DS1, KIR2DL1-5, and KIR2DS1-5. The isoforms have either a short (S) or long (L) cytoplasmic domain which transduce either an activating or inhibitory signal, respectively. The ligands of CD158a (KIR2DL1) are HLA-C molecules with Asn77 and Lys80, but not Ser77 and Asn80.
Additional information: Clone REA284 displays negligible binding to Fc receptors.

Alternative names

KIR2DL1, KIR-K64, KIR221, NKAT, NKAT-1, p58.1

Technical specifications

  • Antigen: CD158a (KIR2DL1)
  • Clone: REA284
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: KIR2DL1, KIR-K64, KIR221, NKAT, NKAT-1, p58.1
  • Entrez Gene ID: 3802
  • Molecular mass of antigen [kDa]: 36
  • Distribution of antigen: NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE-Vio770, PE
  • Selected references

    1. Valés-Gómez, M. et al. (1998) Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors. Immunity 9(3): 337-333
    2. Wagtmann, N. et al. (1995) Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. Immunity 2(5): 439-449
    3. Fan, Q. R. et al. (2001) Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex. Nat. Immunol. 2(5): 452-460
    4. Colonna, M. et al. (1995) Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science 268(5209): 405-408
    5. Jackson, E. et al. (2017) HIV exposed seronegative (HESN) compared to HIV infected individuals have higher frequencies of telomeric killer immunoglobulin-like receptor (KIR) B motifs; contribution of KIR B motif encoded genes to NK cell responsiveness. PLoS One 12(9): e0185160
    6. Chapel, A. et al. (2017) Peptide-specific engagement of the activating NK cell receptor KIR2DS1. Sci. Rep. 7(1): 2414
    7. Lu, W. et al. (2016)
      Suppression of HIV replication by CD8
      +
      regulatory T-cells in elite controllers.
      Front Immunol 7: 134
  • Customer reports and application notes

Product options: 2
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00