CD134 (OX40) antibodies, rat

CD134 (OX40) antibodies, rat

Clone: REA540 | Dilution: 1:10
Clone REA540 recognizes the rat CD134 (OX40) antigen, a 50 kDa glycoprotein which is a member of the TNFR superfamily. It contains a typical signal sequence and a single putative transmembrane sequence of 25 predominantly hydrophobic amino acids giving an extracellular domain of 191 amino acids and a cytoplasmic domain of 36 amino acids. The expression of CD134 is restricted to activated rat CD4
T cells and is up-regulated within hours after activation. CD134 and its ligand CD252 (CD134L, OX40L), which is expressed on activated T and B lymphocytes and also a member of the tumor necrosis factor receptor superfamily, were suggested to mediate the interaction between T cells and B cells.
Additional information: Clone REA540 displays negligible binding to Fc receptors.

Alternative names

TNFRSF4, OX-40, Txgp1, MRC OX40

Technical specifications

  • Antigen: CD134 (OX40)
  • Clone: REA540
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: TNFRSF4, OX-40, Txgp1, MRC OX40
  • Entrez Gene ID: 25572
  • Molecular mass of antigen [kDa]: 28
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Mallett, S. et al. (1990) Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes--a molecule related to nerve growth factor receptor. EMBO J. 9(4): 1063-1068
    2. Calderhead, D. M. et al. (1993) Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions. J. Immunol. 151: 5261-5271
    3. Al-Shamkhanie, A. et al. (1997) Affinity and kinetics of the interaction between soluble trimeric OX40 ligand, a member of the tumor necrosis factor superfamily, and its receptor OX40 on activated T cells. J. Biol. Chem. 272: 5275-5282
Product options: 8
9 µg in 300 µL (1)
EUR 32,00 
30 µg in 1 mL (1)
EUR 67,00 
9 µg in 300 µL (1)
EUR 49,00 
30 µg in 1 mL (1)
EUR 67,00 
9 µg in 300 µL (1)
EUR 56,00 
30 µg in 1 mL (1)
EUR 88,00 
9 µg in 300 µL (1)
EUR 22,00 
30 µg in 1 mL (1)
EUR 36,00 

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