Clone REA918 recognizes the human CD123 antigen, a type I transmembrane glycoprotein, which is also known as interleukin 3 (IL-3) receptor α-chain and is the primary low-affinity subunit of the IL-3 receptor. CD123 associates with CD131, the common β-chain of the IL-3, IL-5, and GM-CSF receptor, to form the high-affinity IL-3 receptor. The IL-3 receptor is involved in cell signaling for cell growth and differentiation. In peripheral blood, the CD123 antigen is expressed at high levels only on plasmacytoid dendritic cells and basophilic granulocytes but at low levels also on monocytes, eosinophilic granulocytes, myeloid dendritic cells, and subsets of hematopoietic progenitor cells.
Additional information: Clone REA918 displays negligible binding to Fc receptors.