CD123 antibodies, human

CD123 antibodies, human

Clone: AC145
CD123 is also known as interleukin 3 (IL-3) receptor α-chain and is the primary low-affinity subunit of the IL-3 receptor. CD123 associates with CD131, the common β-chain of the IL-3, IL-5, and GM-CSF receptor, to form the high-affinity IL-3 receptor. The IL-3 receptor is involved in cell signaling for cell growth and differentiation. In peripheral blood, the CD123 antigen is expressed at high levels only on plasmacytoid dendritic cells and basophilic granulocytes but at low levels also on monocytes, eosinophilic granulocytes, myeloid dendritic cells, and subsets of hematopoietic progenitor cells.

Alternative names

IL3RA, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra, IL-3Rα

Technical specifications

  • Antigen: CD123
  • Clone: AC145
  • Isotype: mouse IgG2a
  • Isotype control: Mouse IgG2a – isotype control antibodies
  • Alternative names of antigen: IL3RA, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra, IL-3Rα
  • Entrez Gene ID: 3563
  • Molecular mass of antigen [kDa]: 41
  • Distribution of antigen: B cells, basophils, bone marrow, brain, endothelial cells, eosinophils, granulocytes, leukemia cells, macrophages, mast cells, megakaryocytes, monocytes, myeloid cells, placenta, red blood cells
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
  • Selected references

    1. Choi, K.-D. et al. (2011) Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells. Nat. Protoc. 6(3): 296-313
    2. van Dongen, J. J. M. et al. (2012) EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes. Leukemia 26(9): 1908-1975
Product options: 1
100 µg in 100 µL
EUR 129,00