CD120a (TNF-RI) antibodies, human

CD120a (TNF-RI) antibodies, human

Clone: REA252 | Dilution: 1:11
Clone REA252 recognizes the extracellular part of the membrane-bound and soluble form of the CD120a antigen, a 55 kDa type I transmembrane glycoprotein also known as tumor necrosis factor receptor type I (TNF-RI) or p55. CD120a belongs to the TNF receptor superfamily and is mainly expressed by monocytes, macrophages, and neutrophils. It is also expressed by a variety of cell lines, tumor cells, and normal cell types including T cells, endothelial cells, hepatocytes, chondrocytes, and fibroblasts. Binding of TNF-α to its main receptor CD120a triggers signaling which is extremely complex, leading to both cell death and survival signals. Sustained activation of TNF signaling has been implicated in the pathogenesis of a wide spectrum of human diseases, including cancer, osteoporosis, sepsis, diabetes, and autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease.
Additional information: Clone REA252 displays negligible binding to Fc receptors.

Alternative names

TNFRSF1A, FPF, MS5, TBP1, p55, p60, TNF-R1

Technical specifications

  • Antigen: CD120a (TNF-RI)
  • Clone: REA252
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TNFRSF1A, FPF, MS5, TBP1, p55, p60, TNF-R1
  • Entrez Gene ID: 7132
  • Molecular mass of antigen [kDa]: 48
  • Distribution of antigen: granulocytes, monocytes, macrophages, neutrophils, T cells, endothelial cells, chondrocytes, fibroblasts, liver, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE-Vio770, Biotin
  • Selected references

    1. Grell, M. et al. (1998) The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor. Proc. Natl. Acad. Sci. U.S.A. 95: 570-575
    2. Bianchi, K. et al. (2009) A tangled web of ubiquitin chains: breaking news in TNF-R1 signaling. Mol. Cell 36(5): 736-742
    3. Hijdra, D. et al. (2012) Differential expression of TNFR1 (CD120a) and TNFR2 (CD120b) on subpopulations of human monocytes. J. Inflamm. 9(1): 38
Product options: 6
for 30
tests
(1)
EUR 75,00 
for 100
tests
(1)
EUR 185,00 
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 
for 30
tests
(1)
EUR 75,00 
for 100
tests
(1)
EUR 185,00 

Related products

2 products available