CD117 antibodies, human

CD117 antibodies, human

Clone: REA996 | Dilution: 1:50
Clone REA996 recognizes the human CD117 antigen, also known as c-kit or SCF receptor. CD117 is a 145 kDa receptor tyrosine kinase involved in stem cell signaling, activation, and proliferation. It is expressed on about 1–3% of peripheral blood mononuclear cells (PBMCs) and cord blood cells and on up to 10% of bone marrow cells. CD117 is further expressed on basophils, myeloid dendritic cells, TCRα/β
+
T cells, CD19
+
B cells, and CD56
+
NK cells, as well as on mast cells, melanocytes, and acute myeloid leukemia (AML) blasts.
Additional information: Clone REA996 displays negligible binding to Fc receptor.

Alternative names

c-kit, KIT, PBT, SCFR

Technical specifications

  • Antigen: CD117
  • Clone: REA996
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: c-kit, KIT, PBT, SCFR
  • Entrez Gene ID: 3815
  • Molecular mass of antigen [kDa]: 107
  • Distribution of antigen: B cells, endothelial cells, fibroblasts, mast cells, megakaryocytes, NK cells, red blood cells, T cells, hematopoietic stem cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, VioBright 515, Biotin
  • Selected references

    1. Yarden, Y. et al. (1987) Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J. 6(11): 3341-3351
    2. Bühring, H. J. et al. (1991) The product of the proto-oncogene c-kit (P145c-kit) is a human bone marrow surface antigen of hematopoietic precursor cells which is expressed on a subset of acute non-lymphoblastic cells. Leukemia 5: 854-860
    3. Guth, S. et al. (1995) Immunomagnetic isolation and surface phenotyping of human c-kit receptor-expressing cells from peripheral blood. 9th International Congress of Immunology
Product options: 8
130-116-730

CD117-PE, human

for 30
tests
(1)
EUR 80,00 
130-116-609

CD117-PE, human

for 100
tests
(1)
EUR 195,00 
130-116-731

CD117-APC, human

for 30
tests
(1)
EUR 80,00 
130-116-610

CD117-APC, human

for 100
tests
(1)
EUR 195,00 
for 30
tests
(1)
EUR 125,00 
for 100
tests
(1)
EUR 300,00 
for 30
tests
(1)
EUR 60,00 
for 100
tests
(1)
EUR 145,00 

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