CD106 (VCAM-1) antibodies, rat

CD106 (VCAM-1) antibodies, rat

Clone: REA1078 | Dilution: 1:50
Clone REA1078 recognizes the CD106 antigen, a 110 kDa transmembrane protein also known as vascular cell adhesion protein 1 (VCAM-1). CD106 is expressed on bone marrow stromal cells, myeloid cells, and dendritic cells, but not on peripheral leukocytes. Expression on endothelial cells is upregulated upon inflammatory cytokine stimulation. CD106 (VCAM-1) is an endothelial ligand for the very late antigen-4 (VLA-4 or α4β1) of the β1 subfamily of integrins, and for integrin α4β7. It mediates the adhesion of lymphocytes, monocytes, eosinophils, and basophils to vascular endothelium. CD106 also functions in leukocyte-endothelial cell signal transduction, and it may play a role in the development of atherosclerosis and rheumatoid arthritis.
Additional information: Clone REA1078 displays negligible binding to Fc receptors.

Alternative names

VCAM1, VCAM1B

Technical specifications

  • Antigen: CD106 (VCAM-1)
  • Clone: REA1078
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: VCAM1, VCAM1B
  • Entrez Gene ID: 25361
  • Molecular mass of antigen [kDa]: 79
  • Distribution of antigen: dendritic cells, endothelial cells, macrophages, stromal cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, VioBright 515, Biotin
  • Selected references

    1. Hession, C. et al. (1992) Cloning of murine and rat vascular cell adhesion molecule-1. Biochem. Biophys. Res. Commun. 183(1): 163-169
    2. Barreiro, O. et al. (2002) Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes. J. Cell Biol. 157(7): 1233-1245
    3. Gao, Z. et al. (2012) Vascular endothelial growth factor participates in modulating the C6 glioma-induced migration of rat bone marrow-derived mesenchymal stem cells and upregulates their vascular cell adhesion molecule-1 expression. Exp Ther Med. 4(6): 993-998
Product options: 12
30 µg in 200 µL (1)
EUR 35,00 
150 µg in 1 mL (1)
EUR 100,00 
30 µg in 200 µL (1)
EUR 65,00 
150 µg in 1 mL (1)
EUR 190,00 
30 µg in 200 µL (1)
EUR 65,00 
150 µg in 1 mL (1)
EUR 190,00 
30 µg in 200 µL (1)
EUR 85,00 
150 µg in 1 mL (1)
EUR 245,00 
30 µg in 200 µL (1)
EUR 120,00 
150 µg in 1 mL (1)
EUR 350,00 
30 µg in 200 µL (1)
EUR 35,00 
150 µg in 1 mL (1)
EUR 100,00