Anti-TTF-1 antibodies, human and mouse

Anti-TTF-1 antibodies, human and mouse

Clone: REA1090 | Dilution: 1:50
TTF-1 (thyroid transcripton factor-1, NKX2.1) is a homeodomain-containing transcription factor. It controls cell differentiation of telencephalic cells and is essential for proper ventral forebrain development. Furthermore, it is a key factor in the morphogenesis and differentiation of the thyroid and lung. TTF-1 is detected in primary lung adenocarcinomas and small cell carcinomas and is absent in colon and breast carcinomas. Analysis of TTF-1 expression is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating from other tumors.
Additional information: Clone REA1090 displays negligible binding to Fc receptors.

Alternative names

NKX2A, TITF1, TTF1, NKX2-1, NKx2.1, Thyroid transcription factor 1

Technical specifications

  • Antigen: TTF-1
  • Clone: REA1090
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: NKX2A, TITF1, TTF1, NKX2-1, NKx2.1, Thyroid transcription factor 1
  • Entrez Gene ID: 7080, 21869
  • Molecular mass of antigen [kDa]: 39
  • Cross-reactivity: rat
  • Distribution of antigen: lung
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, APC-Vio770, Vio515
  • Selected references

    1. Tanaka, H. et al. (2007) Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1. Cancer Res. 67(13): 6007-6011
    2. Li, Y. et al. (2013) NKX2-1 activation by SMAD2 signaling after definitive endoderm differentiation in human embryonic stem cell. Stem Cells Dev. 22(9): 1433-1442
Product options: 12
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EUR 190,00 
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(1)
EUR 95,00 
for 100
tests
(1)
EUR 225,00 
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tests
(1)
EUR 95,00 
for 100
tests
(1)
EUR 225,00 
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 
for 30
tests
(1)
EUR 95,00 
for 100
tests
(1)
EUR 230,00 

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