Anti-TIM-4 antibodies, mouse

Anti-TIM-4 antibodies, mouse

Clone: REA999 | Dilution: 1:50
Clone REA999 recognizes the mouse antigen TIM-4, which is also known as T cell immunoglobulin and mucin domain-containing protein 4 or spleen, mucin-containing, knockout of lymphotoxin protein (SMUCKLER). TIM-4 is a member of the TIM gene family, which is involved in a variety of immunity related processes including T cell proliferation and survival, tissue inflammation, and atopy. In mice, eight TIM genes encode the proteins TIM-1 to TIM-8, whereas only three TIM genes are found in humans encoding TIM-1, TIM-3, and TIM-4. In spleen, TIM-4 is expressed on antigen presenting cells such as lymphoid and myeloid dendritic cells and macrophages but not by T or B lymphocytes.

Alternative names

T-cell immunoglobulin and mucin domain-containing protein 4, TIMD-4, SMUCKLER, TIM4, T-cell membrane protein 4

Technical specifications

  • Antigen: TIM-4
  • Clone: REA999
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: T-cell immunoglobulin and mucin domain-containing protein 4, TIMD-4, SMUCKLER, TIM4, T-cell membrane protein 4
  • Entrez Gene ID: 276891
  • Molecular mass of antigen [kDa]: 35
  • Distribution of antigen: dendritic cells, macrophages
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, PE-Vio770, APC-Vio770, VioBright 515, Biotin
  • Selected references

    1. Shakhov, A. N. et al. (2004) SMUCKLER/TIM4 is a distinct member of TIM family expressed by stromal cells of secondary lymphoid tissues and associated with lymphotoxin signaling. Eur. J. Immunol. 34(2): 494-503
    2. Miyanishi, M. et al. (2007) Identification of Tim4 as a phosphatidylserine receptor. Nature 450(7168): 435-439
    3. Rodriguez-Manzanet, R. et al. (2008) TIM-4 expressed on APCs induces T cell expansion and survival. J. Immunol. 180(7): 4706-4713
Product options: 16
30 µg in 200 µL (1)
EUR 35,00 
150 µg in 1 mL (1)
EUR 100,00 
30 µg in 200 µL (1)
EUR 65,00 
150 µg in 1 mL (1)
EUR 190,00 
30 µg in 200 µL (1)
EUR 65,00 
150 µg in 1 mL (1)
EUR 190,00 
30 µg in 200 µL (1)
EUR 85,00 
150 µg in 1 mL (1)
EUR 245,00 
30 µg in 200 µL (1)
EUR 85,00 
150 µg in 1 mL (1)
EUR 245,00 
30 µg in 200 µL (1)
EUR 85,00 
150 µg in 1 mL (1)
EUR 245,00 
30 µg in 200 µL (1)
EUR 120,00 
150 µg in 1 mL (1)
EUR 350,00 
30 µg in 200 µL (1)
EUR 35,00 
150 µg in 1 mL (1)
EUR 100,00 

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