Anti-TIM-3 antibodies, mouse

Anti-TIM-3 antibodies, mouse

Clone: RMT3-23 | Dilution: 1:10
The monoclonal antibody RMT3-23 reacts with mouse TIM-3, which is a Th-1-specific cell surface protein expressed by differentiated CD4
+
Th1 and CD8
+
Tc1 cells and macrophages. It is absent on CD4
+
Th2 and CD8
+
Tc2 cells. TIM-3 has been proposed to inhibit Th1-mediated immune responses. TIM-3 absence enhances the severity of experimental autoimmune encephalomyelitis in mice. The interaction of TIM-3 and Galectin-9 induces apoptosis of Th1 cells.

Alternative names

HAVCR2, TIMD-3, Tim3

Technical specifications

  • Antigen: TIM-3
  • Clone: RMT3-23
  • Isotype: rat IgG2aκ
  • Isotype control: Rat IgG2a – isotype control antibodies
  • Alternative names of antigen: HAVCR2, TIMD-3, Tim3
  • Entrez Gene ID: 171285
  • Molecular mass of antigen [kDa]: 29
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, Biotin, PE
  • Selected references

    1. Monney, L. et al. (2002) Tʜ1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415: 536-541
    2. van de Weyer, P. S. et al. (2006) A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9. Biochem. Biophys. Res. Commun. 351(2): 571-576
Product options: 3
30 µg in 1 mL (1)
EUR 65,00 
30 µg in 1 mL (1)
EUR 65,00 
30 µg in 1 mL (1)
EUR 35,00 

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