Anti-PI-16 antibodies, human

Anti-PI-16 antibodies, human

Clone: REA699 | Dilution: 1:50
Clone REA699 recognizes the human peptidase inhibitor 16 (PI-16) antigen, also known as CRISP-9 or PSP94-binding protein. PI-16 belongs to the Activity cysteine-rich secretory protein (CRISP) family and is expressed in prostate, testis, ovary, and intestine. It is reported to be an independent prognostic marker for prostate cancer. Additionally, PI-16 is over-expressed by CD4
+
/CD25
+
Treg cells, so it identifies a novel distinct subset of functional memory Treg cells, that are able to migrate to sites of inflammation and regulate the pro-inflammatory response.
Additional information: Clone REA699 displays negligible binding to Fc receptors.

Alternative names

Peptidase inhibitor 16, CRISP-9, PSP94-binding protein

Technical specifications

  • Antigen: PI-16
  • Clone: REA699
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Peptidase inhibitor 16, CRISP-9, PSP94-binding protein
  • Entrez Gene ID: 221476
  • Molecular mass of antigen [kDa]: 47
  • Distribution of antigen: ovary, prostate, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, Biotin
  • Selected references

    1. Reeves, J. R. et al. (2005) Identification, purification and characterization of a novel human blood protein with binding affinity for prostate secretory protein of 94 amino acids. Biochem. J. 385(1): 105-114
    2. Nicholson, I. C. et al. (2012) PI16 is expressed by a subset of human memory Treg with enhanced migration to CCL17 and CCL20. Cell. Immunol. 275(1–2): 12-18
    3. Reeves, J. R. et al. (2006) Prognostic value of prostate secretory protein of 94 amino acids and its binding protein after radical prostatectomy. Clin. Cancer Res. 12(20): 6018-6022
Product options: 8
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 
for 30
tests
(1)
EUR 75,00 
for 100
tests
(1)
EUR 185,00 

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