Anti-Oct3/4 antibodies, human and mouse

Anti-Oct3/4 antibodies, human and mouse

Clone: REA622 | Dilution: 1:11
Clone REA622 recognizes the human and mouse octamer-binding transcription factor 3/4 (Oct3/4). Oct3/4 is a homeodomain transcription factor belonging to the POU transcription factor family and is also known as POU domain class 5 transcription factor 1 (POU5F1). Oct3/4 is critical for the maintenance of totipotency in primate blastomeres and for pluripotency of the inner cell mass of developing mammalian embryos. This critical role of Oct3/4 is maintained in embryonic stem cells, the developing germline, and germline tumors, such as seminomas and embryonic teratocarcinomas. When inducing pluripotency in differentiated cells, Oct3/4 appears to be an essential but not the only required transcription factor. Oct3/4 acts as a transcriptional activator of genes involved in maintenance of undifferentiated state and as a repressor of differentiation-specific genes.
Additional information: Clone REA622 displays negligible binding to Fc receptors.

Alternative names

Oct3/4A, Oct-3A, Oct-4, OTF-3, OTF-4, POU5F1, NF-A3, MGC22487

Technical specifications

  • Antigen: Oct3/4
  • Clone: REA622
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: Oct3/4A, Oct-3A, Oct-4, OTF-3, OTF-4, POU5F1, NF-A3, MGC22487
  • Entrez Gene ID: 5460, 18999
  • Molecular mass of antigen [kDa]: 39, 38
  • Distribution of antigen: embryonic germ cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC
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