Anti-Ly-49G2 antibodies, mouse

Anti-Ly-49G2 antibodies, mouse

Clone: REA1053 | Dilution: 1:50
Clone REA1053 recognizes Ly-49G2, which is a inhibitory receptor specific for class Ia MHC molecules. Ly-49G2 belongs to the Ly-49 multigene family, which consists of type II transmembrane homodimeric receptors. Inhibitory Ly-49 members such as Ly-49G2 contain immunoreceptor tyrosine-based inhibitory motif (ITIM) 3 in their cytoplasmic tail and transduce signal that prevents the NK cell cytolytic activity upon recognizing ligands such as H-2Ddk. Expression of Ly-49G2 is found on subsets of natural killer (NK) cells, NK-T cells, and on a population of memory CD8
+
T cells (in C57BL/6 mice).
Additional information: Clone REA1053 displays negligible binding to Fc receptors

Alternative names

Klra7, LGL-1, Ly49G.4, Ly-49G, Ly49g1, Ly-49G2

Technical specifications

  • Antigen: Ly-49G2
  • Clone: REA1053
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Klra7, LGL-1, Ly49G.4, Ly-49G, Ly49g1, Ly-49G2
  • Entrez Gene ID: 16638
  • Molecular mass of antigen [kDa]: 33
  • Distribution of antigen: NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, VioBright 515, Biotin
  • Selected references

    1. Silver, E. T. et al. (2002) Allelic variation in the ectodomain of the inhibitory Ly-49G2 receptor alters its specificity for allogeneic and xenogeneic ligands. J. Immunol. 169: 4752-4760
    2. Barao, I. et al. (2011)
      Mouse Ly49G2
      +
      NK cells dominate early responses during both immune reconstitution and activation independently of MHC.
      Blood 117: 7032-7041
Product options: 12
30 µg in 200 µL (1)
EUR 35,00 
150 µg in 1 mL (1)
EUR 100,00 
30 µg in 200 µL (1)
EUR 65,00 
150 µg in 1 mL (1)
EUR 190,00 
30 µg in 200 µL (1)
EUR 65,00 
150 µg in 1 mL (1)
EUR 190,00 
30 µg in 200 µL (1)
EUR 85,00 
150 µg in 1 mL (1)
EUR 245,00 
30 µg in 200 µL (1)
EUR 120,00 
150 µg in 1 mL (1)
EUR 350,00 
30 µg in 200 µL (1)
EUR 35,00 
150 µg in 1 mL (1)
EUR 100,00 

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