Anti-Cytokeratin (CK3-6H5) antibodies, human

Anti-Cytokeratin (CK3-6H5) antibodies, human

Clone: CK3-6H5 | Dilution: 1:50
Cytokeratins are typical intermediate filaments of the cytoskeleton of epithelial cells. They are a biochemically highly diverse multigene family of polypeptides with molecular masses ranging from 40 to 68 kDa. Until now 20 distinct cytokeratin polypeptides have been described, which can be divided into an acidic (type I) and a neutral-basic (type II) subfamily. The cytokeratin expression profile within one cell characterizes the type of epithelia and also the degree of maturation or differentiation. Most malignant cells which have their origin in epithelial tissue express a certain cytokeratin profile, which can be used for classifying carcinomas and for distinguishing carcinomas from malignant tumors of nonepithelial origin. The Anti-Cytokeratin (CK3-6H5) antibody is a pan-cytokeratin–specific antibody targeting cytokeratins from simple epithelia. It crossblocks Cam5.2, an antibody specific for cytokeratin 7 and 8, and has been shown to react with native cytokeratin preparations containing cytokeratins 8, 18, and 19 as well as with recombinant cytokeratin 8.

Alternative names

KRT7, KRT8, KRT18, KRT19

Technical specifications

  • Antigen: Cytokeratin
  • Clone: CK3-6H5
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: KRT7, KRT8, KRT18, KRT19
  • Entrez Gene ID: 3855, 3856, 3875, 3880
  • Molecular mass of antigen [kDa]: 44-54
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC
  • Selected references

    1. Makin, C. A. et al. (1984) Monoclonal antibody to cytokeratin for use in routine histopathology. J. Clin. Pathol. 37: 975-983
    2. Balasubramanian, P. et al. (2012) Multiparameter analysis, including EMT markers, on negatively enriched blood samples from patients with squamous cell carcinoma of the head and neck. PLoS One 7(7)
    3. Xin, H. et al. (2014) Establishment and characterization of 7 novel hepatocellular carcinoma cell lines from patient-derived tumor xenografts. PLoS One 9(1): e85308
Product options: 2
for 30
tests
(1)
EUR 75,00 
for 100
tests
(1)
EUR 185,00 

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