Anti-ChemR23 (CMKLR1) antibodies, human

Anti-ChemR23 (CMKLR1) antibodies, human

Clone: REA455
Clone REA455 recognizes the human G-protein–coupled receptor ChemR23 antigen, a multi-pass membrane protein which is also known as chemokine-like receptor 1 (CMKLR1). ChemR23 is expressed by leukocyte populations such as macrophages, immature myeloid and plasmacytoid dendritic cells, as well as on a subset of natural killer (NK) cells. Its natural ligand, chemerin, is a small protein isolated and identified from human inflammatory fluids which acts as a chemoattractant agent for leukocytes expressing ChemR23. Activation of ChemR23 results in intracellular calcium release, inhibition of cAMP accumulation, and phosphorylation of ERK-1/ERK-2 MAP kinases. Chemerin and ChemR23 are involved in the recruitment of NK and dendritic cells (DCs) into tissues in several human inflammatory diseases. They also participate to the regulation of adipocyte metabolism.
Additional information: Clone REA455 displays negligible binding to Fc receptors.

Alternative names

Cmklr1, CHEMERINR, Dez, RVER1

Technical specifications

  • Antigen: ChemR23 (CMKLR1)
  • Clone: REA455
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Cmklr1, CHEMERINR, Dez, RVER1
  • Entrez Gene ID: 1240
  • Molecular mass of antigen [kDa]: 42
  • Distribution of antigen: leukocytes, macrophages, dendritic cells, NK cells
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates:
Product options: 1
100 µg in 100 µL
EUR 144,00