Anti-BMI-1 antibodies, human

Anti-BMI-1 antibodies, human

Clone: REA438 | Dilution: 1:11
Clone REA438 recognizes the human B lymphoma Mo-MLV insertion region 1 homolog (BMI-1) antigen, which is also known as polycomb group RING finger protein 4 (PCGF4). BMI-1 is a member of the polycomb group of transcription repressors that was initially identified as an oncogene cooperating with c-myc in a murine model of lymphoma. Both, hematopoietic stem cells (HSCs) and neuronal stem cells, express high levels of BMI-1. It has been shown that BMI-1 is necessary for efficient self-renewing cell divisions of adult HSCs as well as adult peripheral and central nervous system neural stem cells, but that it is less critical for the generation of differentiated progeny. BMI-1 causes neoplastic proliferation when overexpressed in lymphocytes.
Additional information: Clone REA438 displays negligible binding to Fc receptors.

Alternative names

BMI1, FLVI2/BMI1, PCGF4, RNF51, flvi-2/bmi-1

Technical specifications

  • Antigen: BMI-1
  • Clone: REA438
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: BMI1, FLVI2/BMI1, PCGF4, RNF51, flvi-2/bmi-1
  • Entrez Gene ID: 648
  • Molecular mass of antigen [kDa]: 37
  • Distribution of antigen: hematopoietic stem cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected references

    1. Park, I. K. et al. (2003) Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423(6937): 302-305
    2. Liu, S. et al. (2006) Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res. 66(12): 6063-6071
    3. Park, I. K. et al. (2004) Bmi1, stem cells, and senescence regulation. J. Clin. Invest. 113(2): 175-179
Product options: 6
for 30
tests
(1)
EUR 75,00 
for 100
tests
(1)
EUR 185,00 
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 

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