Anti-BATF antibodies, human

Anti-BATF antibodies, human

Clone: REA486 | Dilution: 1:11
Clone REA486 recognizes the human B cell–activating transcription factor (BATF) antigen, a 14 kDa transcription factor belonging to the AP-1 family of basic leucine zipper transcription factors. BATF plays an important role in regulating differentiation and function in many lymphocyte lineages. In the CD8
+
T cell lineage, increased expression of BATF in exhausted CD8
+
T cells suppresses their effector function. In the CD4
+
T cell lineage, BATF is required for the differentiation of interleukin 17 producing helper T cells, where it binds cooperatively with the transcription factor IRF4 and its dimerization partners c-Jun, JunB, and JunD. BATF is also important for the development of follicular helper T cells by regulating the transcription factors Bcl-6 and c-Maf. In addition, BATF is required for class-switch recombination in B cells and to regulate activation-induced cytidine deaminase as well as DNA damage checkpoint in hematopoietic stem cell self-renewal.
Additional information: Clone REA486 displays negligible binding to Fc receptors.

Alternative names

B-ATF1, SFA-2, SFA2, B-ATF

Technical specifications

  • Antigen: BATF
  • Clone: REA486
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: B-ATF1, SFA-2, SFA2, B-ATF
  • Entrez Gene ID: 10538
  • Molecular mass of antigen [kDa]: 14
  • Distribution of antigen: B cells, leukocytes, T cells, T helper cells, ubiquitous, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected references

    1. Dorsey, M. J. et al. (1995) B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family. Oncogene 11(11): 2255-2265
    2. Li, P. et al. (2012) BATF-JUN is critical for IRF4-mediated transcription in T cells. Nature 490(7421): 543-546
    3. Kurachi, M. et al. (2014)
      The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8
      +
      T cells.
      Nat. Immunol. 15(4): 373-383
Product options: 6
for 30
tests
(1)
EUR 75,00 
for 100
tests
(1)
EUR 185,00 
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 

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