Anti-AKT1 antibodies, human

Anti-AKT1 antibodies, human

Clone: REA134 | Dilution: 1:11
Clone REA134 recognizes AKT1, which is also known as protein kinase Bα. AKT1 is a serine/threonine protein kinase, belonging to the AKT family of kinases and like each AKT family member, contains an N-terminal pleckstrin homology (PH) domain, a central kinase domain, and a carboxyl-terminal regulatory domain with a hydrophobic motif (HM). Activation of AKT1 is achieved via phosphorylation at multiple sites, which take place in response to engagement of receptors such as platelet derived growth factor receptor (PDGF-R). Activated AKT1 further phosphorylates and alters the activity of several downstream substrates allowing AKT1 to play a vital role in various biological processes such as cell growth, survival, migration, and proliferation.
Additional information: Clone REA134 displays negligible binding to Fc receptors.

Alternative names

AKT, CWS6, PKB, PRKBA, RAC, RAC-ALPHA, PKBα

Technical specifications

  • Antigen: AKT1
  • Clone: REA134
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: AKT, CWS6, PKB, PRKBA, RAC, RAC-ALPHA, PKBα
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, PerCP-Vio700
  • Selected references

    1. Calamito, M. et al. (2010) Akt1 and Akt2 promote peripheral B-cell maturation and survival. Blood 115: 4043-4050
    2. Arranz, A. et al. (2012) Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proc. Natl. Acad. Sci. U.S.A. 109(24): 9517-9522
Product options: 8
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 

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