Anti-ADAM15 antibodies, human

Anti-ADAM15 antibodies, human

Clone: REA650 | Dilution: 1:10
Clone REA650 recognizes the human ADAM15 antigen, a transmembrane protein, which contains disintegrin and metalloprotease domains. ADAM15 belongs to the membrane linked metalloproteinase family (ADAM), which has gelatinolytic and collagenolytic activities. It has several functions, for example, it is involved in wound healing process and in glomerular cell migration. Furthermore ADAM15 suppresses beta-1 integrins-mediated cell adhesion and migration of smooth muscle cells.
Expression of ADAM-15 is found in airway smooth muscle, glomerular mesangial cells, colon, small testine, and chondrocytes. It is highly expressed in atherosclerotic lesions.
Additional information: Clone REA650 displays negligible binding to Fc receptors.

Alternative names

ADAM 15, MDC-15, MDC15, Metargidin

Technical specifications

  • Antigen: ADAM15
  • Clone: REA650
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: ADAM 15, MDC-15, MDC15, Metargidin
  • Entrez Gene ID: 8751
  • Molecular mass of antigen [kDa]: 70
  • Cross-reactivity: mouse
  • Distribution of antigen: smooth muscle, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Krätzschmar, J. et al. (1996) Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence. J. Biol. Chem. 271(9): 4593-4596
    2. McKie, N. et al. (1997) Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes. Biochem. Biophys. Res. Commun. 230(2): 335-339
    3. Zhong, J. L. et al. (2008) Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma. Mol. Cancer Res. 6(3): 383-394
Product options: 4
for 30
tests
(1)
EUR 95,00 
for 100
tests
(1)
EUR 225,00 
for 30
tests
(1)
EUR 95,00 
for 100
tests
(1)
EUR 225,00 

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