Mouse IL-2

Mouse IL-2

IL-2 stands for interleukin 2. Mouse IL-2 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.


Mouse IL-2 can be used for a variety of applications, including:
  • In vitro activation and propagation of mouse T cells, e.g., using the T Cell Activation/Expansion Kit, mouse.
  • In vitro activation and expansion of NK cells.
  • Generation of lymphokine-activated killer (LAK) cells.

Background information

Interleukin 2 (IL-2), a potent lymphoid cell growth factor, is a typical four α-helix bundle cytokine. IL-2 is produced by activated T cells, especially the CD4
T helper cell population. It plays an important role in both the activation and maintenance of immune responses and in lymphocyte development. IL-2 promotes proliferation and differentiation of T cells, NK cells, and B cells and is involved in the elimination of self-reactive T cells. IL-2 signals through a receptor complex consisting of IL-2 receptor α-chain (CD25), β- and common γ-chain. The later two are also used for IL-15 signaling.

Quality description

cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Proliferation of mouse CTLL-2 cells
  • research grade: ≥ 5×
  • Selected references

    1. Rodriguez, S. et al. (2011) The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs. Blood 117(24): 6509-6519
    2. Lachance, C. et al. (2013) Exacerbated type II interferon response drives hypervirulence and toxic shock by an emergent epidemic strain of Streptococcus suis. Infect. Immun. 81(6): 1928-1939
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