MACS GMP PepTivator® AdV select

MACS GMP PepTivator
®
AdV select

The MACS GMP PepTivator AdV Select is a peptide pool that consists mainly of 50 lyophilized oligopeptides, consisting of MHC class I and class II restricted peptides derived from different proteins of human adenovirus (AdV), serotypes 2 and 5.
It has been developed for efficient in vitro stimulation and subsequent isolation AdV specific CD4
+
and CD8
+
T cells.

Disclaimer

MACS GMP Products are for research use and
ex vivo
cell culture processing only, and are not intended for human
in vivo
applications. For regulatory status in the USA, please contact your local representative.

Background information

Adenoviruses (AdV) are non-enveloped, ubiquitous, lytic double‑stranded DNA viruses. Up to now, 52 different human serotypes (1–52), divided into six species (A–F), are described. AdV infections are associated with significant morbidity and mortality after hematopoetic stem cell transplantations.

Downstream applications

Antigen-specific T cells play a critical role in the regulation of immune responses and the elimination of virus-infected or malignant cells in the human body. Adoptive transfer of clinical-grade AdV-specific CD4
+
and CD8
+
T cells is a valuable tool for the treatment of AdV infections after hematopoietic stem cell transplantation (SCT)
1
.
The in vitro stimulation of hexon-specific CD4
+
and CD8
+
T cells with MACS GMP PepTivator AdV Select causes the production of the effector cytokine IFN-gamma. The secretion of IFN-gamma then permits the enrichment of hexon-specific effector/memory T cells with the use of the CliniMACS Cytokine Capture System (IFN-gamma).

Quality statement

MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.
  • Certificates

    Please follow this
    link
    to search for Certificates of Analysis (CoA) by lot number.
Product options: 1
for
stimulation of
10
9
cells
EUR 2.495,00 

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