CD80 antibodies, human

CD80 antibodies, human

Clone: 2D10 | Dilution: 1:11
CD80, also known as B7-1, is a 262 amino acid long 60 kDa molecule and a member of the immunoglobulin superfamily. Together with CD86 (B7-2) it belongs to the B7 family of costimulatory molecules. CD80 is expressed on activated B cells, dendritic cells, and monocytes/ macrophages. The interaction of CD80 with its ligands CD28 and CD152 (CTLA-4) plays a critical role in induction and regulation of immune responses. Binding of CD80 to CD28, which is constitutively expressed on T cells, provides a costimulatory signal and induces T cell proliferation and cytokine production. In contrast, binding to CTLA-4 strongly inhibits proliferation and interleukin 2 (IL-2) secretion by T cells.

Alternative names

B7, B7-1, BB1, CD28LG, CD28LG1, LAB7

Technical specifications

  • Antigen: CD80
  • Clone: 2D10
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: B7, B7-1, BB1, CD28LG, CD28LG1, LAB7
  • Entrez Gene ID: 941
  • Molecular mass of antigen [kDa]: 29
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
  • Distribution of antigen: B cells, dendritic cells, Langerhans cells, macrophages, monocytes, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE-Vio770, Biotin, APC
  • Selected references

    1. Linsley, P. S. et al. (1991) Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J. Exp. Med. 173(3): 721-730
    2. Krummel, M. F. et al. (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182(2): 459-465
Product options: 3
for 30
CNY 1,700.00
for 100
CNY 4,080.00
for 100
CNY 3,145.00

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