CD28 antibodies – functional grade, mouse

CD28 antibodies – functional grade, mouse

Clone: 37.51
The CD28 antibody is specific for the mouse CD28 costimulatory molecule, expressed on most thymocytes, CD4
and CD8
T cells, and natural killer (NK) cells. Ligation of CD28 with CD80 (B7-1) and CD86 (B7-2) provides a costimulatory signal for T cell activation. Clone 37.51 has been shown to activate T cells in combination with CD3.
Activation and proliferation of T cells can be induced by interaction of the T cell receptor with peptide-MHC complexes. The T cell receives a signal transduced through the CD3 complex. Cytokines or other costimulatory signals from accessory cells are required in addition. Activated T cells can be used for any downstream processes, such as cytokine analysis or immunoprecipitation. Cells can also be transfected with high efficiency.


The CD28 antibodies – functional grade are suited for functional assays, for example,
in vitro
activation and expansion of T cells in combination with CD2 and CD3 pure – functional grade antibodies, or CD2- and CD3-Biotin – functional grade antibodies, and Anti-Biotin MACSiBead™ Particles, cell culture grade.

Alternative names

T44, Tp44

Technical specifications

  • Antigen: CD28
  • Clone: 37.51
  • Isotype: hamster IgG2λ
  • Alternative names of antigen: T44, Tp44
  • Entrez Gene ID: 12487
  • Molecular mass of antigen [kDa]: 23
  • Distribution of antigen: B cells, lymphocytes, plasma cells, T cells, thymocytes
  • Endotoxin level: Endotoxin levels have been tested and do not exceed 0.01 ng/µg of protein.
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: Biotin, pure
  • Selected references

    1. Gross, J. A. et al. (1992) Identification and distribution of the costimulatory receptor CD28 in the mouse. J. Immunol. 149(2): 380-388
    2. Harding, F. A. et al. (1992) CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356(6370): 607-609
Product options: 2
100 µg in 1 mL
CNY 1,285.00
100 µg in 1 mL
CNY 1,285.00

Related products

2 products available