CD208 (DC-LAMP) antibodies, human

CD208 (DC-LAMP) antibodies, human

Clone: REA295 | Dilution: 1:50
Clone REA295 recognizes the CD208 antigen, a single-pass type I intracellular protein also known as lysosome-associated membrane glycoprotein 3 (LAMP-3) or DC-lysosome–associated membrane glycoprotein (DC-LAMP). CD208 was first cloned as a gene specifically expressed in lung tissues and found to be overexpressed in primary cancers of the esophagus, colon, fallopian tube, ovary, breast, and liver, although its expression was barely detectable in the corresponding normal tissues. It is almost exclusively expressed by mature dendritic cells (DCs). Expression can be induced in CD34
derived dendritic cells by stimulation with GM-CSF and TNF-α or in monocytes by the stimulation with GM-CSF and IL-4. CD208 is found in the MHC class II compartment immediately before the translocation of MHC class II molecules to the cell surface, after which it concentrates into perinuclear lysosomes. This suggests that CD208 might change the lysosome function after the transfer of peptide-MHC class II molecules to the surface of DC.
Additional information: Clone REA295 displays negligible binding to Fc receptors.

Alternative names

LAMP3, DC LAMP, Protein TSC403

Technical specifications

  • Antigen: CD208 (DC-LAMP)
  • Clone: REA295
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: LAMP3, DC LAMP, Protein TSC403
  • Entrez Gene ID: 27074
  • Molecular mass of antigen [kDa]: 42
  • Distribution of antigen: dendritic cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC
  • Selected references

    1. de Saint-Vis, B. et al. (1998) A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment. Immunity 9(3): 325-336
    2. Bell, D. et al. (1999) In breast carcinoma tissue, immature dendritic cells reside within the tumor, whereas mature dendritic cells are located in peritumoral areas. J. Exp. Med. 190(10): 1417-1426
    3. Kanao, H. et al. (2005) Overexpression of LAMP3/TSC403/DC-LAMP promotes metastasis in uterine cervical cancer. Cancer Res. 65(19): 8640-8645
Product options: 2
for 30
CNY 1,530.00
for 100
CNY 3,740.00

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