Anti-Integrin α7 antibodies, mouse

Anti-Integrin α7 antibodies, mouse

Clone: 3C12 | Dilution: 1:50
Clone 3C12 recognizes mouse integrin alpha 7 (Itga7) which belongs to the integrin family of adhesion molecules. Integrins participate in important cell-cell and cell-extracellular matrix interactions in a diverse range of biological processes. Itga7 is a heterodimer consisting of an α and a β subunit and is mainly expressed in skeletal and cardiac muscle. It is a specific cellular receptor for the basement membrane protein laminin-1, as well as for the laminin isoforms-2 and -4 and is involved in differentiation and migration processes during myogenesis. Absence of Itga7 results in muscular dystrophy. It is also required to promote contractile phenotype acquisition in differentiated airway smooth muscle cells.

Alternative names

Itga7, alpha7

Technical specifications

  • Antigen: Integrin α7
  • Clone: 3C12
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: Itga7, alpha7
  • Entrez Gene ID: 16404
  • Molecular mass of antigen [kDa]: 125
  • Distribution of antigen: other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected references

    1. Liu, J. et al. (2008) Increasing alpha 7 beta 1-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expression. Am. J. Physiol., Cell Physiol. 294: C627-C640
    2. Ziober, B. L. et al. (1993) Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during development. J. Biol. Chem. 268: 26773-26783
    3. Mayer, U. et al. (1997) Absence of integrin alpha 7 causes a novel form of muscular dystrophy. Nat. Genet. 17(3): 318-323
Product options: 1
30 µg in 200 µL (1)
CNY 1,105.00

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