Anti-IL-17A antibodies, mouse

Anti-IL-17A antibodies, mouse

Clone: TC11-18H10 | Dilution: 1:50
The Anti-IL-17A antibodies are designed for intracellular staining of IL-17A–producing cells.
Interleukin 17 (IL-17) is a family of cytokines that play a central role in adaptive immunity as well as autoinflammatory disorders.
Data from several mouse models suggest that IL-17 plays a key role in the host defense against certain extracellular bacterial infections.
Recently, a new mouse T helper cell subset has been identified, which is dinstinct from Th1 and Th2 cells: IL-17–producing CD4
T helper (Th17) cells. Th17 cells preferentially produce IL-17A, IL-17F, IL-21, and IL-22. Receptors for IL-17 and IL-22 are expressed on various epithelial tissues, thus Th17 cells are crucial for the cross-talk between immune system and tissues.
It is now established that Th17 cells are responsible for driving autoimmune inflammation.
After stimulation of mouse T cells, IL-17 is not only secreted by CD4
T cells, but also by CD8
T cells and γδ T cells.

Alternative names

CTLA-8, IL-17

Technical specifications

  • Antigen: IL-17A
  • Clone: TC11-18H10
  • Isotype: rat IgG1κ
  • Isotype control: Rat IgG1 – isotype control antibodies
  • Alternative names of antigen: CTLA-8, IL-17
  • Entrez Gene ID: 16171
  • Molecular mass of antigen [kDa]: 15
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC
  • Selected references

    1. Ouyang, W. et al. (2008) The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 28: 454-467
    2. Weaver, C. T. et al. (2007) IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 25: 821-852
Product options: 1
30 µg in 200 µL (1)
CNY 1,105.00

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