Anti-Bcl-6 antibodies, human and mouse

Anti-Bcl-6 antibodies, human and mouse

Clone: REA373 | Dilution: 1:11
Clone REA373 recognizes the human and mouse Bcl-6 antigen, a member of the BTB-zinc finger family of proteins. Bcl-6 is a transcriptional repressor, expressed in germinal center T and B cells and in primary immature dendritic cells. It plays critical functions in various cell types within the adaptive and innate compartments of the immune system. Bcl-6 is highly up-regulated in B cells after T cell–dependent antigenic challenge, and is required for formation of germinal centers within which B cells undergo immunoglobulin affinity maturation. It also plays an important role in macrophages, where it mediates a dampening effect on inflammatory signaling through repression of chemokine expression and NF-κB target genes.
Additional information: Clone REA373 displays negligible binding to Fc receptors.

Alternative names


Technical specifications

  • Antigen: Bcl-6
  • Clone: REA373
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: BCL6, BCL5, BCL6A, LAZ3, ZBTB27, ZNF51
  • Entrez Gene ID: 604, 12053
  • Molecular mass of antigen [kDa]: 79
  • Distribution of antigen: T cells, B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, PE
  • Selected references

    1. Shaffer, A. L. et al. (1997)
      In vivo
      occupancy of the kappa light chain enhancers in primary pro- and pre-B cells: a model for kappa locus activation.
      Immunity 6: 131-143
    2. Huang, C. et al. (2000) Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms. Nat. Immunol. 14(4): 380-388
    3. Kerckaert, J. P. et al. (1993) LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas. Nat. Genet. 5(1): 66-70
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