Clone:
KVa7-6E7
Type of antibody:
Primary antibodies
Isotype:
rat IgG2a
Applications:
ICFC, FC
Alternative names:
CLEC4N, Clec6a, Clecsf10, Nkcl

Specifications for Dectin-2 Antibody, anti-mouse

Overview

Clone KVa7-6E7 specifically recognizes mouse dendritic cell–associated C-type lectin 2 (Dectin-2). Dectin-2 is a type II membrane protein and contains a single carbohydrate recognition domain. Like other C-type lectins, mouse Dectin-2 has conserved motifs for the Ca
2+
-dependent recognition of mannose. Dectin-2 is located in the natural killer gene complex of chromosome 6. Genomic analyses show that beside a full length Dectin-2 transcript two truncated isoforms are produced by alternative splicing, encoding transmembrane proteins of 168–209 amino acids.¹
,
² The expression of Dectin-2 on mouse monocytes and macrophages can be induced by zymosan and thioglycollate.
3
Dectin-2 plays a physiological role in antigen presentation and antigen targeting via Dectin-2 can induce a CD8
+
T cell response.
4

Alternative names

CLEC4N, Clec6a, Clecsf10, Nkcl

Detailed product information

Technical specifications

CloneKVa7-6E7
Clonalitymonoclonal
Isotyperat IgG2a
Isotype controlIsotype Control Antibody, rat IgG2a
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenDectin-2
Alternative names of antigenCLEC4N, Clec6a, Clecsf10, Nkcl
Molecular mass of antigen [kDa]24
Entrez Gene ID56620
RRIDAB_10830717

References for Dectin-2 Antibody, anti-mouse

Publications

  1. Fernandes, M. J. et al. (1999) Characterization of a novel receptor that maps near the natural killer gene complex: demonstration of carbohydrate binding and expression in hematopoietic cells. Cancer Res. 59: 2709-2717
  2. Taylor, P. R. et al. (2005)
    Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited
    in vivo
    .
    Eur. J. Immunol. 35: 2163-2174
  3. Carter, R. W. et al. (2006)
    Induction of CD8
    +
    T cell responses through targeting of antigen to Dectin-2.
    Cell. Immunol. 239: 87-91
  4. Ariizumi, K. et al. (2000) Cloning of a second dendritic cell-associated C-type lectin (dectin-2) and its alternatively spliced isoforms. J. Biol. Chem. 275: 11957-11963

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