Clone:
REA630
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
U-PAR, uPAR

Specifications for CD87 Antibody, anti-mouse, REAfinity™

Overview

Clone REA630 recognizes the mouse CD87 antigen, a key molecule involved in invasive migration of angiogenic endothelium, also known as uPAR. CD87 binds uPA (urokinase plasminogen activator) and thus facilitates the catalytic C domain of the uPA to come in close proximity of membranebound plasminogen. uPA is a serine protease, which converts plasminogen into plasmin which in turn is involved in digestion of various extracellular matrix proteins. CD87 belongs to the Ly6/neurotoxin receptor family and consists of three disulfide-bonded homologous domains, D1, D2, and D3. Function of uPAR is modulated by two inhibitors, PA1 and PA2. CD87 is expressed in angiogenic endothelial cells.
Additional information: Clone REA630 displays negligible binding to Fc receptors.

Alternative names

U-PAR, uPAR

Detailed product information

Technical specifications

CloneREA630
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD87
Alternative names of antigenU-PAR, uPAR
Molecular mass of antigen [kDa]30
Distribution of antigenendothelial cells
Entrez Gene ID18793
RRIDAB_2659411, AB_2659410, AB_2659412, AB_2659413, AB_2659414, AB_2659415, AB_2659416, AB_2659417

References for CD87 Antibody, anti-mouse, REAfinity™

Publications

  1. Miljkovic-Licina, M. et al. (2009) Sushi repeat protein X-linked 2, a novel mediator of angiogenesis. FASEB J. 23(12): 4105-4116
  2. Lin, L. et al. (2010) Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy. J. Biol. Chem. 285(14): 10982-10992
  3. Suh, T. T. et al. (1994) The murine urokinase-type plasminogen activator receptor gene. J. Biol. Chem. 269(42): 25992-25998

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