Clone:
REA452
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CD59a, CD59b, MACIF, MAC-IP, Protectin

Specifications for CD59 Antibody, anti-rat, REAfinity™

Overview

Clone REA452 recognizes the rat CD59 antigen, a 21 kDa glycosylphosphatidylinositol (GPI) linked cell-surface glycoprotein which is also known as MAC-inhibitory protein (MAC-IP), membrane attack complex inhibition factor (MACIF), or protectin. CD59 is widely distributed, being present on all epithelia, endothelia, and on circulating cells, including erythrocytes, monocytes, and some lymphocytes. It inhibits the lytic activity of complement by binding to C8 and C9, thereby blocking the incorporation of mutiple C9 molecules into the membrane attack complex thus preventing functional pore formation.
Additional information: Clone REA452 displays negligible binding to Fc receptors.

Alternative names

CD59a, CD59b, MACIF, MAC-IP, Protectin

Detailed product information

Technical specifications

CloneREA452
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesrat
AntigenCD59
Alternative names of antigenCD59a, CD59b, MACIF, MAC-IP, Protectin
Molecular mass of antigen [kDa]9
Distribution of antigenendothelial cells, epithelial cells, monocytes, lymphocytes
Entrez Gene ID25407
RRIDAB_2658767, AB_2658768, AB_2658769, AB_2658770, AB_2658771, AB_2658772, AB_2658773, AB_2658774, AB_2658775, AB_2658776, AB_2658777, AB_2658766

Resources for CD59 Antibody, anti-rat, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD59 Antibody, anti-rat, REAfinity™

Publications

  1. Rushmere, N. K. et al. (1994) Molecular cloning of the rat analogue of human CD59: structural comparison with human CD59 and identification of a putative active site. Biochem. J. 304(Pt 2): 595-601
  2. Rushmere, N. K. et al. (1997) Expression of rat CD59: functional analysis confirms lack of species selectivity and reveals that glycosylation is not required for function. Immunology 90(4): 640-646
  3. Mizuno, T. et al. (2011) Specific collaboration between rat membrane complement regulators Crry and CD59 protects peritoneum from damage by autologous complement activation. Nephrol. Dial. Transplant. 26(6): 1821-1830

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